Table 3.
Electrophysiological properties of L2/3 pyramidal neurons treated with NS398
| Parameter | WT (P14-P17) |
KO (P14-P17) |
||||||
|---|---|---|---|---|---|---|---|---|
| DMSO |
NS398 |
DMSO |
NS398 |
|||||
| 0 min | 60 min | 0 min | 60 min | 0 min | 60 min | 0 min | 60 min | |
| ISI (ms) | 46.7 ± 7.5 | 45.0 ± 6.5 | 44.5 ± 19.6 | 48.0 ± 14.2 | 32.9 ± 6.2 | 32.5 ± 4.9 | 33.4 ± 8.9 | 43.3 ± 25.6* |
| Rheobase (pA) | 85 ± 20 | 85 ± 40 | 86 ± 25 | 85 ± 29 | 71 ± 24.7 | 72 ± 37 | −73.8 ± 17 | 80 ± 22** |
| RMP (mV) | −65 ± 10 | −66 ± 5 | −65 ± 15 | −67 ± 15 | −64 ± 12 | −63 ± 12 | −64 ± 6 | −69 ± 11* |
| Input resistance (mΩ) | 166 ± 15 | 171 ± 20 | 172 ± 15 | 171 ± 15 | 172 ± 25 | 171 ± 25 | 170 ± 33 | 172 ± 39 |
| No. of cells (mice) | 26 (5) | 26 (5) | 25 (5) | 25 (5) | 39 (6) | 39 (6) | 32 (5) | 32 (5) |
*p < 0.05,
**p < 0.01, compared with KO + NS398 + 0 min. KO: LGI1−/−.