Table 4.
Covariant correlation tests of drug effects between genotypes
| Drugs/proteins | On target (figure) | Regression lines |
Significance (p) | |
|---|---|---|---|---|
| WT | KO | |||
| LGI1 | pcPLA2 (Fig. 3D) | y = −89.8x + 269 | y = −43.5x + 142 | 0.046* |
| NS398 | K+ current at + 40 mV (Fig. 4C) | y = −109.1x + 1166.8 | y = −228.9x + 223.8 | 0.049* |
| NS398 | Synaptic Kv1.2 (Fig. 4D) | y = −x + 101 | y = 43x − 6.2 | 0.0001*** |
| NDGA | ISI (Fig. 4F) | y = 0.3x + 49.4 | y = 0.3x + 38.7 | 0.999 |
| Celecoxib | ISI (Fig. 5C) | y = 1.6x + 42.9 | y = 9.9x + 27.2 | 0.032* |
| Celecoxib | K+ current at + 40 mV (Fig. 5E) | y = −123.4x + 1181.1 | y = 359x + 93.7 | 0.01** |
| Celecoxib | Synaptic Kv1.2 (Fig. 5F) | y = −0.8x + 100.3 | y = 64x − 50.2 | 0.0001*** |
| Celecoxib | Synaptic Cox2 (Fig. 5F) | y = 3.5x + 97.3 | y = −1158.5x − 899 | 0.0001*** |
*p < 0.05,
**p < 0.01,
***p < 0.001, slopes of regression lines compared between WT and LGI1−/− (KO).