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Electrophysiological properties of L2/3 neurons treated with celecoxib
| Parameter | WT (P16) |
KO (P16) |
||
|---|---|---|---|---|
| Saline | Celecoxib | Saline | Celecoxib | |
| ISI (ms) | 44.5 ± 8.5 | 46.1 ± 9.2 | 37.7 ± 6.5 | 44.3 ± 6.1** |
| Rheobase (pA) | 117 ± 22 | 115 ± 23 | 94 ± 15 | 116 ± 23** |
| RMP (mV) | −66 ± 4 | −66 ± 5 | −65 ± 5 | −67 ± 5 |
| Input resistance (MΩ) | 153 ± 18 | 155 ± 18 | 156 ± 20 | 154 ± 19 |
| No. of cells (mice) | 21 (5) | 22 (5) | 26 (5) | 23 (5) |
**p < 0.01 compared with KO + saline. KO: LGI1−/−.
