Table 2. Patterns, size and p-values of significant clusters identified through the STEM algorithm using data from Clarkson et al. [3].
The far right column indicates Involution Specific Gene Signatures through the STEM clustering using data from Clarkson et al. [3].
| Cluster | Pattern* | Size | p-Value | Number of human orthologous genes identified | Signature name |
|---|---|---|---|---|---|
| #1 | 0,1,2,3,4,5 | 270 | 1.30E-234 | 256 | Inv1 |
| #2 | 0,-1,2,1,1,1 | 120 | 1.10E-54 | 118 | Inv2 |
| #3 | 0,-1,-2.-3.-4.-5 | 74 | 3.00E-26 | 69 | Inv3 |
| #4 | 0,-3,-1,-1,0,1 | 50 | 5.10E-11 | 47 | Inv4 |
| #5 | 0,3,0,-3,-3,-2 | 46 | 7.30E-08 | 43 | Inv5 |
| #6 | 0,-3,-4,-2,-3,-3 | 77 | 1.20E-07 | 76 | Inv6 |
| #7 | 0,-3,-4,-5,-6,-3 | 40 | 2.30E-05 | 39 | Inv7 |
| #8 | 0,-2,1,2,4,1 | 32 | 1.10E-04 | 31 | Inv8 |
| #9 | 0,2,1,0,2,5 | 39 | 5.70E-04 | 37 | Inv9 |
| #10 | 0,2,5,3,6,3 | 26 | 7.30E-04 | 26 | Inv10 |
*Pattern indicates the log2 fold change in gene expression levels of lactation day 10 and involution days 0.5, 1, 2, 3 and 4 days compared lactation day 10.