Table 1. A table summarising the fitness and lethality parameters used throughout this study.

Within the mathematical model numbers of each transgenic construct carried by a particular genotype (i) are denoted ${\eta }_i^A$ and ${\eta }_i^B$ for transgenic constructs A and B, respectively. Also shown within this table are the lethality parameters (γ_i) used to define each of the gene drive elements with γ = 1 representing 100% effective lethality whilst γ = 0 denotes a viable genotype. Here the different gene drives considered are denoted UD (engineered underdominance) and KR (killer-rescue) with SS and WS representing strong and weak suppression of lethals, respectively. Here strong suppression of lethals refers to the scenario whereby one copy of a suppressor transgene is sufficient to rescue against two copies of the associated lethal transgene, whereas for weak suppression two suppressor copies are required to save against two lethal copies. For killer-rescue constructs, parameter values were selected such that construct A represents the killer and B the rescue.

		Constructs Carried		Lethal Effect (γi)
i	Genotype	${\eta }_i^A$	${\eta }_i^B$	UD (SS)	UD (WS)	KR (SS)	KR (WS)
1	aabb	0	0	0	0	0	0
2	aaBb	0	1	1	1	0	0
3	aaBB	0	2	1	1	0	0
4	Aabb	1	0	1	1	1	1
5	AaBb	1	1	0	0	0	0
6	AaBB	1	2	0	1	0	0
7	AAbb	2	0	1	1	1	1
8	AABb	2	1	0	1	0	1
9	AABB	2	2	0	0	0	0