Figure 1. Mortality and clinical features of aGvHD in the GR^dim model.

GR^wt and GR^dim BALB/c mice were transplanted with BM and purified T cells from C57BL/6 wildtype mice; transfer of BM cells only served as a control. (A) Survival of mice was monitored for 42 days. N = 11 (BM), N = 10 (GR^wt), N = 22 (GR^dim); data pooled from multiple experiments. (B) Body temperature of mice was analyzed on day 6. N = 6 (BM), N = 7 (GR^wt), N = 9 (GR^dim); data pooled from multiple experiments. (C, D) Mice were sacrificed on day 6 and serum levels of IL-6 (C) and IFNγ (D) were analyzed by ELISA. N = 7 (BM), N = 9 (GR^wt), N = 6 (GR^dim) for IL-6; N = 7 (BM), N = 13 (GR^wt), N = 15 (GR^dim) for IFNγ; data pooled from multiple experiments. All values are depicted as the mean ± SEM. Survival curves were compared using the Gehan-Breslow-Wilcoxon test, statistical analyses of body temperature and cytokine levels were performed by Mann-Whitney U test (^*p < 0.05; ^**p < 0.01; ^***p < 0.001; n.s.: non-significant).