Figure 2. CSP and its analogues on the bacterial cell membrane do not lead to antibiotic resistance.

(A, B) Development of resistance in S. aureus CCARM 29213 cells exposed to CSP-4, daptomycin, or linezolid at pH 5.5 and pH 7.4. The Y-axis shows the relative change in MIC from the first passage. All values represent the mean ± SD of three individual experiments (p < 0.05, one-way ANOVA).