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. 2018 Feb 28;9(21):15721–15731. doi: 10.18632/oncotarget.24595

Figure 1. Combined high expression of Ang-2 and VEGFA associates with survival and increased IL-8 expression.

Figure 1

The expression level of ANGPT2 (A), VEGFA (B) and the combined high expression of ANGPT2 and VEGFA (C) associated with poorer survival of GBM patients (TCGA cohort). The differential expression of these factors (above or below median) did not associate with microvascular density (D), vessel size (E) or vessel perimeter (F) (Groningen cohort). Individual values per patient are displayed and horizontal lines represent median scores. (G) Profiling of several angiogenic mRNAs identified IL8 and MMP9 as the targets upregulated most in the tumors with combined high expression of ANGPT2 and VEGFA; *P < 0.05, **P < 0.01.