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. 2018 Feb 28;9(21):15721–15731. doi: 10.18632/oncotarget.24595

Figure 2. Ang-2 and VEGFA expression associate with increased IL-8 expression.

Figure 2

In the Groningen cohort tumors with higher than median ANGPT2 expression (A) and tumors with higher than median expression of ANGPT2 and VEGFA (C) expressed significantly higher levels of IL-8 mRNA as well. A similar but non-significant trend was observed for tumors with above median expression of VEGFA (B). Box-and-whiskers were generated according to Tukey’s method with the box representing the 25th and 75th percentile, and whiskers represent 1.5 × IQR. Values outside these intervals are plotted as individual points. The expression levels of ANGPT2 (D), VEGFA (E) and IL-8 (F), explored in the larger TCGA cohort, were all positively correlated; *P < 0.05, ***P < 0.001.