Table 2. Univariate and multivariate analyses of possible prognostic parameters for OS of GBM patients in the TCGA and REMBRANDT cohort.

Characteristic	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
TCGA cohort (n = 525)
ANGPT2	1.344 (1.103–1.637)	0.003	1.015 (0.745–1.384)	0.924
VEGFA	1.260 (1.036–1.532)	0.021	0.952 (0.712–1.273)	0.740
ANGPT2*VEGFA	1.524 (1.238–1.875)	<0.001	1.562 (1.021–2.388)	0.040
REMBRANDT cohort (n = 151)
ANGPT2	1.212 (0.869–1.690)	0.256
VEGFA	1.261 (0.905–1.758)	0.171
ANGPT2*VEGFA	1.518 (1.055–2.185)	0.024