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Superposition of the acetylated sisomicin (gray carbon atoms) structure in the binary enzyme–acetyl sisomicin complex on the ternary enzyme-CoASH-sisomicin (cyan protein carbon atoms, with sisomicin carbon atoms colored green and CoASH carbon atoms colored orange) structure. The acetylation of sisomicin leads to flipping of the adjacent sugar ring concomitant with active-site rearrangement that would lead to loss of CoASH product hydrogen bonds.
