Table 2.

Circadian clock genes abnormalities in cancer

Abnormality	Cancer type	Reference
Per gene mutation	breast, colorectal	62
Deregulation of Per gene expression	breast, colorectal, endometrial, lung, CLL, DLBL, AML, CML	28, 29, 59-61, 86-89
Single nucleotide polymorphisms in circadian genes associated with cancer risk and patient survival	breast, prostate, NHL	30, 31, 65-67
Per1 translocation	CML	90

Abbreviations: CLL, Chronic lymphocytic leukemia; DLBCL, Diffuse large B-cell lymphoma; AML, acute myeloid leukemia; CML, chronic myeloid leukemia; NHL, non-Hodgkin’s lymphoma.