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Positive chronotropic but null inotropic responses of hES2-derived ventricular microtissues (hvCMTs) to β-adrenergic stimulation. A, Image of a typical hvCMT on a microfabricated tissue gauge device. B, Representative raw tracings of hvCMT at the baseline (upper) and after 10 μmol/L isoproterenol (Iso) treatment (down). C, Iso increased the spontaneous twitch frequency (n=5; **P<0.01). D, Iso did not affect the developed twitch tensions (P=0.729).
