Table 1.
Quantitative APTw intensity values and the corresponding diagnostic performance for MGMT unmethylated and methylated GBMs.
| Unmethylated | Methylated | P value |
AUC (95% Confidence interval) |
Cut-off value |
Sensitivity | Specificity | Accuracy | |
|---|---|---|---|---|---|---|---|---|
| Mean | 2.54±0.41 | 2.01±0.42 | 0.022* | 0.825 (0.626–1.000) | 2.26 | 87.5% | 80% | 83.3% |
| Variance | 1.01±0.34 | 0.59±0.24 | 0.01 1* | 0.837 (0.649–1.000) | 0.94 | 62.5% | 90% | 77.8% |
| Skewness | 0.04±0.52 | 0.06±0.87 | 0.963 | |||||
| Kurtosis | 4.67±1.93 | 4.80±3.48 | 0.934 | |||||
| 10th percentile | 1.40±0.53 | 1.06±0.45 | 0.186 | |||||
| 50th percentile | 2.54±0.36 | 1.99±0.41 | 0.012* | 0.850 (0.672–1.000) | 2.25 | 75% | 80% | 77.8% |
| 90th percentile | 3.71±0.45 | 2.93±0.53 | 0.006* | 0.856 (0.674–1.000) | 3.25 | 87.5% | 70% | 77.8% |
| Width10–90 | 2.31±0.42 | 1.87±0.41 | 0.049* | 0.763 (0.537–0.988) | 2.15 | 62.5% | 80% | 72.2% |
| Mode | 2.45±0.38 | 2.05±0.47 | 0.086 |
Note: APTw values were recorded as average ± standard deviation (% of the water signal intensity). AUC is the area under the ROC curve. Significant difference (p < 0.05) was marked by a *.