Figure 2. Preclinical brain imaging and neurosurgery.
A, Concurrent MRI (top) and bioluminescence (bottom) imaging of the same mouse with a SEP-CR(+) tumor. B, Correlation of MRI and bioluminescence imaging of the same cohort of five mice with SEP-CR(+) tumors. C, Preclinical mouse neurosurgical protocol. D–H, (left) bioluminescence measurement of tumor growth. In parenthesis are the days (d) when treated tumor volume was significantly (p<0.05, non-parametric) less than control. (Right) survival curves of mice with indicated animal numbers and tumor types treated with surgery or control. P value=Log Rank relative to control.
