Table 30.

Antiviral activity results of test compounds (c2–c4) in cell culture

Compounds	ECa50 (µmol/ml)			CCb50
	HIV (IIIB)	HIV-2 (ROD)	MSV	(µmol/ml) (CEM)
c2	0.011	0.0045	0.0095	≥ 0.3
c3	0.0045	0.0027	0.021	≥ 0.3
c4	0.080	0.050	–	≥ 0.2
Adefovir	0.0033	0.0066	0.0022	0.056
Tenofovir	0.0012	0.0014	0.0046	0.14

^a50% effective concentration; ^b 50% cytostatic concentration