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In vitro antimalarial activity of N-aryl and heteroaryl sulfonamide derivatives
| Compounds | P. falciparum (IC50 in µM (µg/ml)) | |||
|---|---|---|---|---|
| P. falciparum (D6) | P. falciparum (W2) | |||
| IC50 | SI | IC50 | SI | |
| d11 | 4.86 (2.3) | > 10.8 | 6.39 (3.02) | > 8.2 |
| d12 | 2.56 (1.38) | > 18 | 3.41 (1.84) | > 13.5 |
| Artemisinin | < 0.09 (< 0.03) | – | < 0.09 (< 0.03) | – |
| Chloroquine | < 0.08 (< 0.03) | – | 0.72 (0.23) | – |
