Table 40.

Anti-inflammatory activity of pyrimidine derivatives

Comp.	Percent inhibition ± SEM at various time intervals
	0.5 h	1.0 h	2.0 h	3.0 h	4.0 h	6.0 h
e8	15.22 ± 0.68*	50.45 ± 1.23*	87.23 ± 2.61*	62.51 ± 2.33*	56.94 ± 1.79	48.39 ± 2.65
e9	18.26 ± 0.68*	49.35 ± 1.41*	86.99 ± 2.62*	62.13 ± 2.25*	53.32 ± 2.01	42.11 ± 2.75
Ibuprofen	20.26 ± 0.90*	53.95 ± 0.97*	97.09 ± 2.86*	79.97 ± 2.38*	67.93 ± 2.22*	58.02 ± 1.87*

All values are represented as mean ± SEM (n = 6). *P < 0.01 compared to saline control group. One-way ANOVA, Dunnett’s t test. Dosage: Ibuprofen-10 mg/kg and test compounds-10 mg/kg body weight by orally