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. 2018 Apr 4;8:5625. doi: 10.1038/s41598-018-23912-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structure and effect of cyperenoic acid on cell viability and inflammatory response in RAW264.7 macrophage like cell line. (A) The chemical structure of cyperenoic acid isolated from Croton crassifolius is shown. (B) RAW264.7 cells or (C) BMs-derived osteoclast precursors were treated with various concentrations of cyperenoic acid for 24 h and cell viability was determined by MTT assay. The IC₅₀ for cell viability is ≥100 µM. (D) RAW264.7 cells were stimulated with or without LPS (100 ng/ml) and IFN-γ (10 ng/ml) in the presence of various concentrations of cyperenoic acid or vehicle control DMSO. The amount of nitric oxide produced in the culture supernatant was measured. The data are representative of three independent experiments and presented as the mean ± S.D.