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. 2018 Apr 4;8:5663. doi: 10.1038/s41598-018-23939-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Therapeutically multifunctional adhesive systems using copper doped bioactive glass nanoparticles. Schematically illustrated the multifunctional roles of Ca and Cu ions delivered through nanoparticles (CuBGn) in adhesive resin. The co-delivery of Ca and Cu ions respectively accelerate remineralization and MMP deactivation in demineralized dentin, and ultimately extend the longevity of resin-dentin interfaces dentin regeneration. TEM images (right images) of CuBGn with EDS results (insert, n = 3) confirming the designated composition of nanoparticles.