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. 2018 Apr 4;6:11. doi: 10.1038/s41413-018-0009-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MYC regulates super enhancer genes in osteosarcoma. a Overlap between MYC binding sites and super enhancer regions in U2OS cells. Brown circle represents the size of MYC target; blue circle represents the size of super enhancers. b Groups of super enhancer regions based on MYC binding status. The super enhancers were separated into two different groups based on their MYC binding statuses. c Distribution of MYC bound super enhancers in different genomic regions. d, e Gene ontology analysis of MYC bound super enhancer associated genes. d Cellular component gene ontology; e disease gene ontology (color figure online).