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. 2018 Apr 4;6:11. doi: 10.1038/s41413-018-0009-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Super enhancer inhibitors suppress osteosarcoma proliferation and induce apoptosis. a Western blotting of MYC expression in different cells, β-Actin was used as loading control. b MTS assay of U2OS, 143B, and BJ cell proliferation under treatment of THZ1. Cells were treated with different concentration of THZ1 and DMSO and planted into 96-well cell culture plate at 1 000 cells/well, then cell proliferation was measured by OD490 at day4 after treatment. c Cells were treated with indicated concentration of THZ1 or DMSO for 48 h, then the cell apoptosis was measured by the Caspase 3/7 activities using the Caspase-Glo® 3/7 Assay Systems. d MTS assay of U2OS proliferation under treatment of JQ1. e analysis of apoptosis in U2OS cells treated with JQ1. n = 3. **P < 0.01, ***P < 0.001.