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. 2018 Apr 4;8:5628. doi: 10.1038/s41598-018-23963-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of the designed competitive LFA for ampicillin detection. Aptamer-mFc-AuNP conjugates are incubated with biotinylated CRP in the presence or absence of ampicillin. If ampicillin is absent, the conjugates will bind towards biotinylated CRP and will be immobilized on the test line with streptavidin (A). If ampicillin is present, CRP is displaced from the aptamer, leading to a signal decrease on the test line (B). In both cases, the mFc on the conjugates leads to an immobilization on the control line via the α-mouse antibody, generating the control line.