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. 2018 Apr 4;8:5652. doi: 10.1038/s41598-018-24009-7

Figure 2.

Figure 2

Luciferase activity from ten haplotypes of the HLA-G 5′URR in choriocarcinoma JEG-3 cell line treated with (A) 5 µM cyclopamine; (B) 1000 U/mL interferon-β; and (C) 1 µg/mL progesterone. The data represent the mean SEM. The Wilcoxon matched pairs test was used for comparisons between treated and untreated transfectants. *P < 0.05; **P < 0.01. (D) Association analysis of the specific polymorphic sites near to targets of IFN-β, progesterone and cyclopamine. The data represent the median with the minimum and maximum values. The statistical analysis was performed by Mann-Whitney test. The four independent experiments were performed in duplicate.