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. 2018 Apr 4;8:5655. doi: 10.1038/s41598-018-24024-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flow chart of the study. 20 patients were enrolled for the intensive phase of the study which lasted for ten consecutive hemodialysis sessions. In every subject, OER was measured six times during each of the first 6 HD sessions, while in dialysis sessions 7 to 10 OER was measured only twice, in ten patients only. Ten further patients were enrolled for the clinical follow-up phase. HD_Long = Hemodialysis following long interdialytic interval; HD_Short = Hemodialysis following short interdialytic interval; iD = isolated dialysis; iUF = isolated ultrafiltration.