Table 3.
Properties of genomes of novel species compared to these of close relatives and one other species isolated from a snake host. T3SS: type III secretion system, PLD: Phospholipase D.
| Species | C. pneumoniae | C. serpentis | C. caviae | C. poikilothermis | Ca. C. sanzinia |
|---|---|---|---|---|---|
| Host | Human | Snake | Guinea pigs | Snake | Snake |
| Disease | pneumonia/bronchitis | undetermined | genital/ocular | undetermined | undetermined |
| Strain | CWL029 | H15-1957-10C | GPIC | S15-834K | 2742-308 |
| Accession number(s) | AE001363 | ERZ462351-2 | AE015925-6 | ERZ462353-4 | CP014639 |
| Publication | Kalman NG 1999 (41) | This publication | Read NAR 200339 | This publication | Taylor-Brown BMCG14 |
| Genome size | 1230230 | 1198609 | 1173390 | 1155104 | 1113073 |
| Predicted CDSs | 1073 | 985 | 1009 | 979 | 998 |
| Plasmid | N (only in strain N16) | 7533 bp | 7966 bp | 7559 bp | 7504 bp |
| dDDH | 22.60% | 30.90% | |||
| Novel species probability | 98.50% | 100% | |||
| ANI genome | 80.82% | 86.01% | |||
| Virulence associated | |||||
| ompA | Cpn_0695 | C10C_0661 | CCA_00047 | C834K_0054 | Cs308_0329/0497 |
| T3SS | Y | Y | Y | Y | Y |
| tarp | Cpn_0572 | C10C_0530 | CCA_00170 | C834K_0183 | Cs308_0200 |
| tarp repeats | N | Y | N | N | Y |
| pmp genes | 22 (6 pseudogenes) | 18 | 18 (1 pseudogene) | 19 (3 pseudogenes) | 19 (2 pseudogenes) |
| Locus_tags | Cpn_0005, 0013, 0444-7, 0451, 0453-4, 0466-7, 0471, 0539-40, 0963 | C10C_0005,0007-8, 0410-4, 0416, 0419-20, 0424-7, 0495-6, 0936 | CCA_00205-6, 00271-5, 00277-84, 00624, 00806 | C834K_0221-2, 0291-7, 0299, 0302-5, 0642, 0828 | Cs308_0065, 0068, 0078, 0080, 0163-4, 0586 |
| pmp clusters | 4 | 4 | 4 | 4 | 4 |
| bioABD | Cpn_1041-4 | C10C_1013-8 | N - replaced by phage fragment | C834K_0742 (bioB) | Cs308_0663-6 |
| udk/upp | Cpn_0735 (udk) | C10C_0705 (udk) | N | N | N |
| incA, B, C | Cpn_0186, 0585, 0291-2 | C10C_0160, 0545, 0261-2 | CCA_00550, 00491-0 | C834K_0578, 0817, 0516-5 | Cs308_0059, 0863-4 |
| Two incA homologues | Two incA homologues | Two incA homologues | |||
| PZ/RTR | |||||
| accBC | Cpn_0182-3 | C10C_0156-7 | CCA_00553-4 | C834K_0581-2 | Cs308_0799-800 |
| guaAB-add | Cpn_0170-2 (pseudogenes) | Cs0C_0149-52 | CCA_00572-4 | C834K_0590-2 | N |
| cytotoxin | N | N | CCA_00558 | N | N |
| PLD | N | N | N | N | N |
| MAC/perforin | Cpn_0176 | C10C_0153 | CCA_00560 (pseudogene) | N | N |
| trp operon | N | N | CCA_00562-7 | N | N |
| Pseudogenes (curated) | Cpn_0014-5 (pmp) | C10C_0926 (ispE) | CCA_00285 (pmpG) | C834K_0289 (pmp) | Cs308_0073 (pmp) |
| Cpn_0016-7 (pmp) | CCA_00288 (gatA) | C834K_0300 (pmp) | Cs308_0075 (pmp) | ||
| Cpn_0018-9 (pmp) | CCA_00326 (hypothetical) | C834K_0310 (pmp) | |||
| Cpn_0170 (add) | CCA_00515 (hypothetical) | C834K_0638 (hypothetical) | |||
| Cpn_0171 (guaA) | CCA_00560 (MAC/perforin) | C834K_0657 (cons. hypothet) | |||
| Cpn_0267-8 (incA) | CCA_00886 (invasin) | ||||
| Cpn_0339-41 (recF) | |||||
| Cpn_0449-50 (pmp) | |||||
| Cpn_0452 (pmp) | |||||
| Cpn_0470 (pmp) | |||||
| Cpn_0954-5 (ispE) | |||||