Table 2.
Factors, hematology, biochemistry, FiO2, and PaO2/FiO2 on admission day 7.
| Factors | Univariate analysis | ||
|---|---|---|---|
| Ventilator-dependent (N = 72) | Ventilator-independent (N = 179) | p-value | |
| Age, years, mean ± SD | 69.40 ± 15.65 | 64.59 ± 15.67 | 0.028 |
| Age > 69 y/o | 42 (58.3) | 76 (42.5) | 0.023 |
| Male sex, No. (%) | 42 (58.3) | 111 (62.0) | 0.589 |
| APACHE II | 24.80 ± 8.51 | 24.22 ± 9.34 | 0.664 |
| Initial SOFA score | 8.15 ± 3.52 | 8.80 ± 3.50 | 0.184 |
| Charlson index | 2.79 ± 2.08 | 2.36 ± 1.85 | 0.111 |
| Underlying comorbidities, No. (%) | |||
| oronary artery disease | 22 (30.6) | 35 (19.6) | 0.060 |
| Hypertension | 40 (55.6) | 108 (60.3) | 0.486 |
| Chronic obstructive pulmonary disease | 7 (9.7) | 23 (12.8) | 0.490 |
| Asthma | 2 (2.8) | 4 (2.2) | 0.799 |
| Cirrhosis | 6 (8.3) | 12 (6.7) | 0.651 |
| Diabetes mellitus | 28 (38.9) | 86 (48) | 0.188 |
| A history of stroke | 22 (30.6) | 32 (17.9) | 0.027 |
| Chronic kidney disease | 21 (29.2) | 40 (22.3) | 0.255 |
| Pulmonary tuberculosis | 10 (5.6) | 4 (5.6) | 1.000 |
| With malignancy | 26 (14.5) | 16 (22.2) | 0.140 |
| White blood cells, 10 × 103/μl | 12.03 ± 8.01 | 11.87 ± 5.16 | 0.857 |
| Hemoglobin, g/dl | 10.05 ± 1.66 | 10.57 ± 1.59 | 0.024 |
| Platelet, 1000/μL | 177.09 ± 97.17 | 234.66 ± 138.86 | <0.001 |
| Prothrombin time, sec | 12.33 ± 1.29 | 12.44 ± 1.25 | 0.527 |
| INR | 1.19 ± 0.13 | 1.20 ± 0.12 | 0.487 |
| AST, U/L | 58.03 ± 44.31 | 54.13 ± 41.39 | 0.508 |
| ALT, U/L | 51.51 ± 39.35 | 64.04 ± 88.05 | 0.247 |
| BUN, mg/dL | 47.51 ± 37.16 | 38.70 ± 29.94 | 0.076 |
| Creatinine, mg/dL | 2.06 ± 2.17 | 1.95 ± 2.29 | 0.706 |
| Na, meq/L | 141.21 ± 6.17 | 138.89 ± 11.31 | 0.102 |
| K, meq/L | 3.89 ± 0.72 | 3.86 ± 0.72 | 0.791 |
| C-reactive protein, mg/L | 77.41 ± 77.45 | 55.03 ± 47.30 | 0.025 |
| Albumin, g/dL | 3.52 ± 3.49 | 4.21 ± 12.33 | 0.638 |
| Lactate, mmol/L | 1.52 ± 0.67 | 1.46 ± 0.55 | 0.470 |
| Procalcitonin, ng/mL | 8.17 ± 24.45 | 5.21 ± 8.83 | 0.319 |
| pH | 7.44 ± 0.67 | 7.46 ± 0.45 | 0.009 |
| PaCO2, mmHg | 40.92 ± 12.14 | 38.29 ± 6.92 | 0.087 |
| Bicarbonates, mmol/L | 27.21 ± 6.96 | 26.89 ± 4.86 | 0.723 |
| FiO2, % | 39.46 ± 11.90 | 35.02 ± 3.43 | 0.003 |
| PaO2/FiO2, mmHg | 269.46 ± 91.22 | 297.50 ± 83.48 | 0.020 |
Abbreviations: APACHE, Acute Physiologic and Chronic Health Evaluation; SOFA, Sequential Organ Failure Assessment; INR, International Normalized Ratio; AST, Aspartate Aminotransferase; ALT, Alanine Aminotransferase; FiO2, Fraction of Inspired Concentration of Oxygen.