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. 2018 Apr 4;8:5616. doi: 10.1038/s41598-018-23589-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NIPTmer results for 289 subjects of Belgian cohort. Chromosome 21 (A), chromosome 18 (B) and chromosome 13 (C). Samples are ordered on the x-axis by the order of subject enrollment. The y-axis represents the standardized deviation (z-score) between the predicted and observed coverage of given chromosome. Euploid samples are represented by gray points and aneuploidy samples by red points. All non-mosaic aneuploidies, including T21 (15/15), T18 (10/10), and T13 (3/3), had higher z-scores than the highest control score, although the difference between lowest trisomy and highest normal score was small for trisomies 18 and 21. Unfortunately, we could not detect one mosaic T13 with our pipeline.