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. 2018 Apr 4;8:5623. doi: 10.1038/s41598-018-23955-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Macroscopic (top panel) and transmission electron microscopic (bottom panel) analysis of saltwater crocodile tissues infected with poxvirus. Belly skin of juvenile saltwater crocodile showing poxvirus lesions as defined by Moore et al.³ (A) has an early active (black arrow) and active (white arrowhead) poxvirus lesion in the mid-scale region, (B) has an active lesion on the upper scale margin, and (C) shows poxvirus lesions along two linear blemishes ranging from the active to expulsion stages. Different stages of virus maturation (D–F) including immature virion (IV) (E, white arrow), and intracellular mature virion (IMV) (F, orange arrow) were imaged by transmission electron microscopy.