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. 2018 Mar 29;9:301. doi: 10.3389/fphar.2018.00301

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Copyright © 2018 Wang, Dai, Song, Zhu, Liu, Hou, Ke, Zhou, Qiu, Wang, Jiang, Jia and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of LLC on autophagy in H9c2 cardiomyocytes under OGD. (A) Expression levels of LC3, Beclin 1 and p62 changes with LLC pretreatment. (B) Expression levels of LC3 and p62 changes in the presence or absence of 5 μmol⋅L^-1 chloroquine and 40 μg⋅mL^-1 LLC. (C) H9c2 cardiomyocytes were transfected with mRFP-GFP-LC3 and observed by fluorescent microscope (scale bar = 10 μm). (D) Mean number of autophagosomes represented by yellow dots in merged images and autolysosomes represented by red dots in merged images per cell. All experiments were repeated at least three times. Data were presented as means ± SD. ^∗∗P < 0.01 vs. Con group, ^##P < 0.01 vs. OGD group, ^&P < 0.05, ^&&P < 0.01 vs. OGD+LLC group, ^$P < 0.05 vs. OGD+CQ group. CQ, chloroquine.