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. 2018 Mar 29;9:619. doi: 10.3389/fimmu.2018.00619

Figure 6.

Figure 6

Preemptive transforming growth factor (TGF)β neutralization attenuates progressive glomerular filtration rate (GFR) decline. C57BL/6N mice were either fed a control diet (control), a high-oxalate diet (oxalate only) or an oxalate-rich diet combined with preemptive IgG1 or anti-TGFβ antibody treatment (oxalate + IgG1 and oxalate + anti-TGFβ) for up to 14 days. (A–D) Representative images of FITC-sinistrin fluorescence intensity curves using the three-compartment model with linear correction from a healthy mouse (control) (A), a mouse with nephrocalcinosis (B), an IgG1-treated mouse (C), or anti-TGFβ antibody-treated mouse (D) with nephrocalcinosis. (E) GFR decline of all four groups from day 0 to 14 illustrated by the effect sizes: linear equation with slope (m, colored lines), GFR on day 14, and time to end stage renal disease (ESRD) (dotted lines and table). Δ represents difference expressed in percent (%). Data are mean ± SEM from five to seven mice per group and representative of one out of two independent experiments.