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. 2018 Mar 29;12:84. doi: 10.3389/fncel.2018.00084

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Copyright © 2018 Lin, Murphy, Karlsson, Petralia, Gutzmann, Abebe, Wang, Cameron and Hoffman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DPP6-KO mice show impaired recognition memory. (A) Schematic of the spatial object recognition paradigm. (B) WT mice show increased time spent in exploring the moved object, while DPP6-KO mice do not show a difference in time exploring the moved object at test trial compared to training trial. (C) DPP6-KO mice showed no recognition between familiar and moved object but WT showed significant increase of recognition of the moved object. (D) Schematic of the Novel object recognition paradigm. (E) WT mice spend more time exploring the novel object at testing trial. However, DPP6-KO mice do not show a preference for the novel object over a familiar object. (F) WT mice showed greater recognition of the novel object, but DPP6-KO mice show no significant preference between the novel and familiar object (*p < 0.05, **p < 0.01, ***p < 0.001).