Table 1.
Synaptic structures of the hippocampal CA1 region in WT and DPP6 knockout (DPP6-KO) adult mice.
| WT (mean ± SEM) | DPP6-KO (mean ± SEM) | T value (degree of freedom) | |
|---|---|---|---|
| PSD surface area (nm2) | 10611 ± 298 | 7157 ± 161*** | T(448) = 10.7 |
| n = 203 | n = 247 | ||
| PSD perimeter (nm) | 524 ± 10 | 431 ± 6*** | T(448) = 8.2 |
| n = 203 | n = 247 | ||
| PSD thickness (nm) | 54 ± 0.7 | 44 ± 0.5*** | T(525) = 11.7 |
| n = 238 | n = 289 | ||
| PSD length (nm) | 244 ± 4 | 205 ± 3*** | T(435) = 7.3 |
| n = 220 | n = 217 | ||
| PSD mean intensity | 77 ± 0.8 | 65 ± 0.9*** | T(448) = 9.8 |
| n = 203 | n = 247 | ||
| Cleft width (nm) | 16.8 ± 0.3 | 17.5 ± 0.3n.s | T(387) = 1.7 |
| n = 176 | n = 213 | ||
| Cleft mean intensity | 94 ± 1 | 81 ± 1*** | T(387) = 7.8 |
| n = 176 | n = 213 | ||
| Spine head area (nm2) | 94330 ± 3592 | 66264 ± 2204*** | T(509) = 6.8 |
| n = 241 | n = 270 | ||
| Spine perimeter (nm) | 1163 ± 22 | 994 ± 16*** | T(509) = 6.4 |
| n = 241 | n = 270 | ||
| Spine mean intensity | 127 ± 0.9 | 118 ± 1*** | T(509) = 6.4 |
| n = 241 | n = 270 | ||
| Synapses density (Synapses/μm2) | 0.53 ± 0.02 | 0.48 ± 0.01* | T(366) = 2.0 |
| n = 174 images | n = 194 images |
*p < 0.05; ***p < 0.001; n.s. = not significant, Student’s t-test.