Table 2.
Total cell lysates of myeloid cells from the specific granule deficiency (SGD) patients and normal donors (ND) and a polymorphonuclear (PMN) fraction of healthy controls (HCs) were prepared as for Table 1.
| Protein name | Uniprot entry name | Spectral counts SGD | Spectral counts HC | Spectral counts PMN-undil | Biological process |
|---|---|---|---|---|---|
| Vimentin | VIME_HUMAN | 108.5 (97/120) | 0 (0/0) | 0 (0/0) | Nuclear organization |
| Nesprin-2 | SYNE2_HUMAN | 55.5 (28/83) | 0 (0/0) | 1.5 (3/0) | Nuclear organization |
| Unconventional myosin-XVIIIa | MY18A_HUMAN | 28 (16/40) | 0 (0/0) | 0 (0/0) | Intracellular trafficking |
| Far upstream element-binding protein 2 | FUBP2_HUMAN | 25.5 (17/34) | 0 (0/0) | 0 (0/0) | RNA processing |
| Monocyte differentiation antigen CD14 | CD14_HUMAN | 19.5 (21/18) | 0 (0/0) | 0 (0/0) | Cell differentiation |
| Type-1 angiotensin II receptor-associated protein | ATRAP_HUMAN | 18 (14/22) | 0 (0/0) | 0 (0/0) | Intracellular trafficking |
| Serrate RNA effector molecule homolog | SRRT_HUMAN | 14 (4/24) | 0 (0/0) | 0 (0/0) | RNA processing |
| Ribosomal protein S6 kinase alpha-3 | KS6A3_HUMAN | 12 (10/14) | 0 (0/0) | 0 (0/0) | Translation |
| Dedicator of cytokinesis protein 8 | DOCK8_HUMAN | 11.5 (7/16) | 0 (0/0) | 0 (0/0) | Cell differentiation |
| U5 small nuclear ribonucleoprotein | U520_HUMAN | 11.5 (8/15) | 0 (0/0) | 0 (0/0) | RNA processing |
| Eukaryotic initiation factor 4A-III | IF4A3_HUMAN | 11 (12/10) | 0 (0/0) | 0 (0/0) | Translation |
| 40S ribosomal protein S4, X isoform | RS4X_HUMAN | 11 (10/12) | 0 (0/0) | 0 (0/0) | Translation |
| Coiled-coil domain-containing protein 88B | CC88B_HUMAN | 10.5 (11/10) | 0 (0/0) | 0 (0/0) | Cell differentiation |
| 40S ribosomal protein S3 | RS3_HUMAN | 10.5 (10/11) | 0 (0/0) | 0 (0/0) | Translation |
| Splicing factor, proline- and glutamine-rich | SFPQ_HUMAN | 10 (5/15) | 0 (0/0) | 0 (0/0) | RNA processing |
| Splicing factor 3B subunit 3 | SF3B3_HUMAN | 40.5 (32/29) | 1 (2/0) | 0 (0/0) | RNA processing |
| Neuroblast differentiation-associated AHNAK | AHNK_HUMAN | 111 (90/132) | 3 (6/0) | 0 (0/0) | Unknown |
| Lamin-B2 | LMNB2_HUMAN | 20.5 (17/24) | 1 (2/0) | 0 (0/0) | Nuclear organization |
| FK506-binding protein 15 | FKB15_HUMAN | 10 (6/14) | 0.5 (1/0) | 0.5 (1/0) | Unknown |
The identified proteins are listed according to decreasing spectral count ratio (ND/SGD). Spectral counts for each duplicate are indicated in brackets.