Fig. 2.

Effect of chronic administration HBK-14 and fluoxetine on the behavior of mice treated with corticosterone. Corticosterone (20 mg/kg) was injected subcutaneously (s.c.) for 3 weeks at random times during the light phase. Additionally, 30 min before, corticosterone administration mice were intraperitoneally (i.p.) injected with HBK-14 (1.25 or 2.5 mg/kg), fluoxetine (10 mg/kg), or 0.9% NaCl (saline). Control groups received saline (i.p.) and 30 min later saline containing 0.1% dimethyl sulfoxide (DMSO) and 0.1% Tween-80 (vehicle, s.c.). The doses are indicated in brackets. Statistical analysis: one-way ANOVA (Newman–Keuls post hoc); *p < 0.05, **p < 0.01 vs control (non-corticosterone-treated) (saline, gray); ^# p < 0.05, ^### p < 0.001 vs corticosterone-treated control (saline, red); ^{^} p < 0.05 vs fluoxetine; n = 8 mice per group (color figure online)