Table 4.

Effect of a single administration of studied compounds on locomotor activity in mice

Treatment	Dose of the studied compound (mg/kg)	Number of crossings ± S.E.M
Saline + vehicle	–	246.5 ± 34.6
Saline + corticosterone	–	230.7 ± 15.8
HBK-15 + corticosterone	1.25	245.3 ± 22.5
Ketamine + corticosterone	1	248.7 ± 25.3
Fluoxetine + corticosterone	15	231.9 ± 21.9

Corticosterone (20 mg/kg) was injected subcutaneously (s.c.) to mice for 3 weeks at random times during the light phase. Thirty minutes before, the experiment mice were intraperitoneally (i.p.) injected with HBK-15 (1.25), ketamine (1 mg/kg), fluoxetine (15 mg/kg), or 0.9% NaCl (saline). Control group, which was injected for 21 days with saline containing 0.1% dimethyl sulfoxide (DMSO) and 0.1% Tween-80 (vehicle, s.c.), received saline (i.p.). Statistical analysis: one-way ANOVA (Newman–Keuls post hoc); n = 8 mice per group