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Impact of temporal hypoxia on the biology of oligodendrocytes. The processes of oligodendroglial differentiation, maturation and the capability for myelinogenesis are highly energy-consuming and are supported by metabolites provided by circulating, oxygenated blood (upper panel). Perinatal asphyxia leads to a decrease in blood pressure and a temporal limitation in oxygen and glucose supply (lower panel). Maturation of oligodendrocytes is arrested and myelinogenesis is altered/delayed
