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. 2017 Jun 28;55(5):4388–4402. doi: 10.1007/s12035-017-0647-7

Fig. 4.

Fig. 4

The scheme of targets for therapeutic intervention after perinatal asphyxia. The first and most effective is head cooling applied immediately after the injury, aimed at avoiding/limiting injures resulting from temporal hypoxia-ischemia. Current strategies are based on preventing the development of leukodystrophic disorders (anti-oxidative, neuroprotective are myelin-preserving protocols) and favoring endogenous neuroreparative mechanisms (providing anti-inflammatory therapeutics and trophic support)