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. 2018 Mar 29;9:647. doi: 10.3389/fimmu.2018.00647

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Copyright © 2018 Cao, Huang, Xia, Liu, Muhammad and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression homeobox a5 (Hoxa5) downregulated inflammation genes and upregulated thermogenic genes in adipocytes. (A) Heatmap of genes set from RNA-seq data with forced expression of Hoxa5 in mice adipocytes, along with the top affected genes (n = 3). (B) Gene ontology (GO) analysis of the altered genes in (A) (n = 3). (C) Analysis of altered pathway enrichment in response to forced expression of Hoxa5 (n = 3). (D,E) Changes in the mRNA level of genes associated with inflammation and browning, which were significantly altered from RNA-seq analysis (n = 3). Values are represented as means ± SEM. *p < 0.05 compared with the control group.