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. 2018 Mar 29;9:647. doi: 10.3389/fimmu.2018.00647

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Copyright © 2018 Cao, Huang, Xia, Liu, Muhammad and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylation level of homeobox a5 (Hoxa5) is decreased along with increasing browning in adipose of cold exposed mice. (A) The schematic diagram of CpGs Hoxa5 promoter. (B) Relative mRNA level of Hoxa5 in inguinal white adipose tissue (iWAT) after 8 h cold exposure at 4°C (n = 6). (C) The methylation level of CpG in −148 bp ~ −14 bp of the Hoxa5 promoter in iWAT of mice with or without 8 h cold exposure at 4°C (n = 10). (D) Relative mRNA level of Hoxa5, Dnmt1, Dnmt3a, Mbd3, UCP1, PGC1α, and Cidea in iWAT with 5-AZA injection (n = 8). (E) Relative mRNA level of Hoxa5, Dnmt1, IL1β, and TNFα in adipocytes with or without 5-AZA under lipopolysaccharide (LPS) treatment (n = 4). Values are represented as means ± SD vs. control group, *p < 0.05.