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. 2018 Mar 29;9:647. doi: 10.3389/fimmu.2018.00647

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Copyright © 2018 Cao, Huang, Xia, Liu, Muhammad and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Homeobox a5 (Hoxa5) promotes white adipose tissue browning through reducing tenascin C (TNC)/toll-like receptor (TLR) 4/nuclear factor kappa B (NF-κB) inflammatory signaling in mice. Hoxa5 promotes adipose tissue browning by activating BMP4/Smad1 signal and alleviating inflammation via inhibiting TNC/TLR4/NF-κB pathway.