Figure 1.

Selective breakdown of B cell tolerance to key inflammatory cytokines/chemokines regulates cancer, autoimmunity and infectious diseases: selective breakdown of tolerance to chemokines and cytokines may result from the generation of an inflammatory process at sites that are partially restricted from immune surveillance (autoimmune sites, tumor sites) or as a results of a deficiency in central tolerance (APS1/APECES patients with autoimmune regulator deficiency). In both, it is believed that breakdown of B cell tolerance follows the breakdown of T cell tolerance. The data obtained from APS1/APECES patients strongly support this hypothesis.