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. 2017 Nov 21;67(1):97–109. doi: 10.1099/jmm.0.000627

Table 1. Summary of gross necropsy, histological and microbiological findings from cases 1 and 2, and archived case.

Case Gross findings Histopathologic diagnoses Culture site results
1* Focal pale tan discoloration at dorsal base of the heart; pale circumferential dark circular lesions on splenic surface; mottled and tan serosal surface of kidney; cortical pitting on surface of left kidney; 3 implantation sites in left horn of uterus Streptococcal septicaemia
Severe multifocal acute necrotizing suppurative myocarditis, epicarditis and valvular endocarditis with intra-lesional cocci
Moderate multifocal acute suppurative necrotizing splenitis with intra-lesional cocci
Moderate multifocal neutrophilic and histiocytic interstitial pneumonia with vasculitis and fibrin thrombi admixed with bacteria
Moderate multifocal acute suppurative necrotizing nephritis with intra-lesional cocci
Mild multifocal acute suppurative meningoencephalitis
Severe multifocal acute necrotizing suppurative metritis with intra-lesional cocci
BloodStreptococcus agalactiae
Cardiac lesionS. agalactiae - 3 isolates
SpleenS. agalactiae, Enterobacter aerogenes, Staphylococcus sciuri, Enterococcus faecalis
Vaginal swabS. agalactiae, S. sciuri, E. aerogenes, Proteus mirabilis, E. coli, E. faecalis
Cervical contents – S. agalactiae, E. faecalis - 2 isolates, E. aerogenes, P. mirabilis, Enterococcus avium
2* 3–4 tan to pale yellow plaque-like lesions on the pericardium extending into the parenchyma; two pinpoint dark red to haemorrhagic lesions on the lung surface; left kidney with pinpoint tan-white focal lesions extending 1.5 mm into the parenchyma; mildly distended uterus with 1 haemorrhagic and autolysed fetus in each horn Severe multifocal acute necrotizing myocarditis, epicarditis and endocarditis with atrial and ventricular thrombi admixed with intra-lesional cocci
Moderate multifocal subacute neutrophilic and histiocytic interstitial pneumonia
Severe multifocal acute necrotizing suppurative metritis with intra-lesional cocci
Mild multifocal subacute lymphocytic pancreatitis
Streptococcal septicaemia
Nares washS. agalactiae, E. faecalis, Streptococcus mitis, S. sciuri, E. aerogenes - S. agalactiae, E. faecalis, Streptococcus mitis, S. sciuri, E. aerogenes
Cardiac lesion – S. agalactiae - S. agalactiae
Lung -–S. agalactiae, E. faecalis, E. avium, E. coli - S. agalactiae, E. faecalis, E. avium, E. coli
KidneyS. agalactiae - S. agalactiae
BrainS. agalactiae, E. faecalis, Streptococcus oralis - S. agalactiae, E. faecalis, Streptococcus oralis
Vaginal swabS. agalactiae, E. faecalis, E. avium, E. coli, Morganella morganii, P. mirabilis - S. agalactiae, E. faecalis, E. avium, E. coli, Morganella morganii, P. mirabilis
Uterine swabS. agalactiae, E. faecalis, E. avium, E. coli
FetusS. agalactiae, E. faecalis - 2 isolates, E. coli
Archived case† Ventricular thrombus; autolysed fetus‡ Septic right ventricular thrombosis with Gram-positive and -negative bacteria
Grossly fibrinopurulent inflammation of the placenta, macerated fetus
Renal abscess with Gram-positive bacteria
Severe submassive and centrilobular hepatic necrosis
Pleural effusion
Extramedullary splenic myelopoiesis
Cardiac thrombusS. agalactiae, P. mirabilis, E. coli
FetusS. agalactiae, P. mirabilis, E. coli

*Histopathology reviewed by V. B.

†Histopathology reviewed by L. R.

‡Notes from necropsy of archived case with GBS-related pathology not further detailed.