Table 3.
Vascular measures by group
Variable | Group | ||
---|---|---|---|
| |||
Children | Adults | P-value | |
Baseline Diameter (mm) | 3.07 ± 0.04 | 3.79 ± 0.04 | < 0.0001 |
Peak FMD (% from baseline) | 7.25 ± 0.28 | 6.47 ± 0.18 | 0.022 |
Peak Shear rate (sec−1) | 314 ± 8.38 | 278 ± 4.92 | 0.0002 |
ShearAUC (sec−1) | 13231 ± 531 | 9907 ± 237 | < 0.0001 |
ShearAUC 0-peak flow (sec−1) | 3231 ± 135 | 2569 ± 67 | < 0.0001 |
FMDAUC (% sec−1) | 715 ± 35.2 | 602 ± 20.5 | 0.008 |
FMD Time to Peak (sec) | 57.2 (53.3, 61.4) | 52.8 (50.5, 55.1) | 0.027 |
Time to Peak Shear (sec) | 11.8 (11.1, 12.6) | 10.6 (10.2, 11.0) | 0.004 |
FMDTTP-ShearTTP (sec) | 42.9 (38.9, 47.4) | 40.2 (38.0, 42.6) | 0.27 |
Variables represented: flow mediated dilation (FMD), shear area under the curve (ShearAUC), ShearAUC from cuff deflation to peak flow (0-peakflow), FMD under the curve (FMDAUC), FMD time to peak (FMDTTP), Shear Time to peak (ShearTTP). Baseline Diameter, Peak FMD, ShearAUC, and FMDAUC are mean ± SEM, FMD time to peak and Time to Peak shear values are back-transformed and represent geometric mean (95% CI), P-value < 0.05 demonstrates significant differences between means (two sided).