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Chimeric antigen receptor (CAR) structure and design. A) Three generations of CARs. CAR compromises 3 domains: extracellular domain; transmembrane domain; and cytoplasmic domain. First generation CAR only has CD3ζ domain; second-generation CAR incorporates CD28 or 4-1BB, while the third-generation CAR incorporates both or more. B) Primary CARs design and evolution
