Table 1.
List of CAR targets in haematological and solid tumor
| I. Haematological tumor CAR targets | ||
|---|---|---|
| Target | Gene | Description |
| BCMA | TNFRSF17 | TNF receptor superfamily member 17\B-cell maturation protein |
| CD123 | IL3RA | interleukin 3 receptor subunit α\CD123 antigen |
| CD138 | SDC1 | syndecan 1 |
| CD19 | CD19 | CD19 molecule |
| CD20 | MS4A1 | membrane spanning 4-domains A1 |
| CD22 | CD22 | SIGLEC2 |
| CD38 | CD38 | CD38 molecule |
| CD5 | CD5 | lymphocyte antigen T1/Leu-1 |
| Ig κ chain | IgK | immunoglobulin κ locus |
| LeY | FUT3 | fucosyltransferase 3 (Lewis Blood Group) |
| NKG2D ligand | NKG2D | killer cell lectin like receptor K1/CD314 |
| ROR1 | ROR1 | receptor tyrosine kinase like orphan receptor 1 |
| WT1 | WT1 | Wilms’ tumour antigen 1 |
| II. Solid tumour CAR targets | ||
| Target | Gene | Description |
| C-Met | MET | MET proto-oncogene |
| CAIX | CA9 | carbonic anhydrase 9 |
| CD133 | PROM1 | prominin 1 |
| CD171 | L1CAM | L1 cell adhesion molecule |
| CD70 | CD70 | tumour necrosis factor ligand superfamily member 7 |
| CEA | CEACAM5 | carcinoembryonic antigen related cell adhesion molecule 5 |
| EGFR | EGFR | epidermal growth factor receptor |
| EGFR vIII | EGFRVIII | epidermal growth factor receptor variant 3 |
| Ep-CAM | EPCAM | epithelial cell adhesion molecule |
| EphA2 | EPHA2 | EPH receptor A2 |
| FAP | FAP | fibroblast activation protein α |
| GD2 | disialoganglioside | |
| GPC3 | GPC3 | glypican 3 |
| HER2 | ERBB2 | Erb-B2 receptor tyrosine kinase 2 |
| HPV16-E6 | HPV E6 | human papillomavirus E6 protein |
| IL13Ra2 | IL13RA2 | interleukin 13 receptor subunit α2 |
| LeY | FUT3 | fucosyltransferase 3 (Lewis Blood Group) |
| MAGEA3 | MAGEA3 | MAGE family member A3 |
| MAGEA4 | MAGEA4 | MAGE family member A4 |
| MART1 | MLANA | melan-A |
| Mesothlin | MSLN | mesothelin |
| MUC1 | MUC1 | mucin 1, cell surface associated |
| MUC16 | MUC16 | mucin 16, cell surface associated |
| NY-ESO-1 | CTAG1B | cancer/testis antigen 1B |
| PD-L1 | CD274 | CD274 molecule |
| PSCA | PSCA | prostate stem cell antigen |
| PSMA | FOLH1 | folate hydrolase 1 |
| ROR1 | ROR1 | receptor tyrosine kinase like orphan receptor 1 |
| VEGFR2 | KDR | kinase insert domain receptor/vascular endothelial growth factor receptor 2 |