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. 2018 Mar 21;18(1):51–62. doi: 10.3727/105221617X15124876321401

Figure 7.

Figure 7

Effect of Oct4 inhibition on hepatocytes. Representative photomicrographs of hepatocyte-specific HNF-4α following Oct4 inhibition in organoid culture tissue samples on day 21. (A, B) Treated with AD-Scr. (C, D) Treated with AD-Oct4. Thick arrows indicate HNF-4α− cells. Thin arrows indicate HNF-4α+ cells. Original magnification: 400×. Cell counts of hepatocytes and biliary epithelial cells following Oct4 inhibition. (E) Biliary-to-hepatocyte ratio and (F) number of hepatocytes. Significantly different from AD-Scr control: **p ≤ 0.01.