Table 3. Treatment-Emergent Adverse Drug Reactions Among HIV-Positive Patients With Tuberculosis Receiving 3 Antituberculosis Therapy Regimens.
| Toxic Effect Type | Grade of Toxic Effects | Regimena | ||
|---|---|---|---|---|
| Daily (n = 111) | Part-Daily (n = 110) | Intermittent (n = 110) | ||
| Gastrointestinal and hepatic | 1 and 2 | 5 | 1 | 8 |
| 3 and 4 | 11 | 11b | 2 | |
| Neurological | 1 and 2 | 11 | 8 | 8 |
| 3 and 4 | 1 | 1 | 0 | |
| Cutaneous | 1 and 2 | 1 | 0 | 1 |
| 3 and 4 | 1c | 0 | 0 | |
| Others | 1 and 2 | 0 | 0 | 0 |
| 3 and 4 | 0 | 2d | 0 | |
| Overall adverse drug reactions, No. (%) | 30 (27) | 23 (21) | 19 (17) | |
a
Four patients had permanent discontinuation or modification of antituberculosis therapy.
b
Two patients had jaundice.
c
One patient had Stevens-Johnson syndrome.
d
One patient had thrombocytopenia.