Table 2. Associations Between Prediction Variables and Survival.
| Characteristic | Hazard Ratio (95% CI)a | Simplified Score Points | |||
|---|---|---|---|---|---|
| Full Multiple Variable | P Value | Final | P Value | ||
| Age, y | |||||
| 30-45 | 2.64 (1.51-4.61) | <.001 | 2.42 (1.47-4.00) | <.001 | 4 |
| >45 | 8.50 (4.92-14.7) | <.001 | 6.82 (4.20-11.1) | <.001 | 8 |
| Men | 1.20 (0.91-1.58) | .20 | NA | NA | NA |
| Log(No. of CTG repeats) | |||||
| (2 × 55) − (2 × 86) | 1.17 (0.80-1.71) | .43 | NA | NA | NA |
| (2 × 87) − (3 × 52) | 1.24 (0.86-1.79) | .26 | NA | NA | NA |
| Diabetes | 1.78 (1.20-2.63) | .004 | 1.73 (1.25-2.39) | .001 | 2 |
| Dyslipidemia | 0.90 (0.64-1.25) | .52 | NA | NA | NA |
| Smoking | 1.25 (0.91-1.71) | .17 | NA | NA | NA |
| Dysphagia | 1.10 (0.79-1.52) | .59 | NA | NA | NA |
| Need for walking support | 2.04 (1.29-3.20) | .002 | 1.88 (1.27-2.79) | .002 | 3 |
| Heart rate, beats per min | |||||
| 63-73 | 1.36 (0.97-1.90) | .07 | 1.32 (0.98-1.78) | .07 | 1 |
| ≥74 | 1.45 (1.04-2.02) | .03 | 1.41 (1.05-1.90) | .02 | 1 |
| Systolic blood pressure, mm Hg | |||||
| ≤110 | 1.42 (1.04-1.93) | .03 | 1.36 (1.03-1.79) | .03 | 1 |
| 111-121 | 1.00 (0.71-1.40) | .99 | 1.00 (0.74-1.35) | .99 | 0 |
| Atrial fibrillation | 1.04 (0.66-1.64) | .85 | NA | NA | NA |
| First-degree atrioventricular block | 1.32 (0.99-1.75) | .06 | 1.34 (1.04-1.72) | .02 | 1 |
| Bundle-branch block | 1.43 (1.07-1.91) | .02 | 1.45 (1.12-1.87) | .005 | 1 |
| Left ventricular ejection fraction, % | |||||
| 60-66 | 0.86 (0.62-1.19) | .36 | NA | NA | NA |
| >66 | 0.82 (0.57-1.18) | .29 | NA | NA | NA |
| Vital capacity, % predicted value | |||||
| 60-90 | 1.25 (0.87-1.78) | .22 | 1.29 (0.94-1.76) | .12 | 1 |
| ≤60 | 2.27 (1.48-3.46) | <.001 | 2.32 (1.63-3.30) | <.001 | 3 |
Abbreviation: NA, not applicable.
a
The hazard ratios were pooled over the 35 imputed data sets. Hazard ratios in the final model are shrunk by the calibration slope (0.904).