Table 2. Multiple Linear Regression Model Estimates for Associations Between EDS and ΔPiB in Aβ-Susceptible Regions of Interest^a.

Region of Interest	Modela
	All Elderly Individuals Without Dementia		Individuals With Global PiB Positivityb
	B Coefficient (95% CI)	P Value	B Coefficient (95% CI)	P Value
Prefrontal	0.025 (−0.005 to 0.055)	.10	0.048 (−0.007 to 0.104)	.08
Anterior cingulate	0.031 (0.001 to 0.061)	.04	0.065 (0.010 to 0.118)	.02
Cingulate-precuneus	0.038 (0.006 to 0.069)	.02	0.068 (0.009 to 0.126)	.02
Parietal	0.033 (0.001 to 0.065)	.04	0.054 (−0.008 to 0.116)	.12

Abbreviations: ΔPiB, difference between the second and first Pittsburgh B compound (PiB) uptake measures; EDS, excessive daytime sleepiness.

^aModels were controlled for baseline age, interval between scans, sex, apolipoprotein E ε4 allele, educational level, baseline regional PiB uptake, baseline global PiB positivity (all individuals model only), midlife physical activity, cardiovascular comorbidities (obesity, hypertension, hyperlipidemia, and diabetes), reduced sleep duration, respiratory symptoms during sleep (snoring, choking, or witnessed apneas), and depression.

^bIndicates standardized uptake value ratio of at least 1.4.